UNC Lineberger News

Combination therapy for triple-negative breast cancer disappointing

Combination therapy for triple-negative breast cancer disappointing

CHAPEL HILL, N.C. – A recent clinical trial testing a combination therapy for basal-like (also known as triple-negative) breast cancer demonstrates that a combination of two drugs with promising preclinical results is not as effective as researchers had hoped.

Combination therapy for triple-negative breast cancer disappointing - Read More…

Gene inactivation drives spread of melanoma

Gene inactivation drives spread of melanoma

Chapel Hill, NC – Why do some cancers spread rapidly to other organs and others don’t metastasize? A team of UNC researchers led by Norman Sharpless, MD, have identified a key genetic switch that determines whether melanoma, a lethal skin cancer, spreads by metastasis.

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Jennifer Bowman named Hometown Hero for June 11

Jennifer Bowman named Hometown Hero for June 11

WCHL named Jennifer Bowman a Hometown Hero for June 11, 2012. Each weekday the station selects a Hometown Hero who goes “over and above the call of duty,” exemplifying excellent service and dedication to others in the community.

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Mayer appointed to term on Cancer Survivorship Committee

Mayer appointed to term on Cancer Survivorship Committee

Deborah Mayer, PhD, RN, AOCN, FAAN, associate professor in the UNC School of Nursing, has been appointed to a three-year term on the Cancer Survivorship Committee of the American Society of Clinical Oncology.

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UNC Lineberger member James Evans quoted in Nature

UNC Lineberger member James Evans quoted in Nature

James P. Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine, is quoted in an article discussing the fetal genome and the possibility of clinic procedures being introduced in the next couple of years.

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UNC Lineberger member Kurt Ribisl co-authors study assessing online alcohol sales to minors

UNC Lineberger member Kurt Ribisl co-authors study assessing online alcohol sales to minors

Kurt Ribisl, PhD, is co-author of the article “Internet Alcohol Sales to Minors” published online ahead of print in the May 2012 issue of the Archives of Pediatrics & Adolescent Medicine.

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Bae-Jump receives grant to study impact of obesity on ovarian cancer

Bae-Jump receives grant to study impact of obesity on ovarian cancer

Victoria Bae-Jump, MD, PhD, has received a two-year $200,000 grant from the Department of Defense, to study “Preclinical and Clinical Investigations of the Impact of Obesity on Ovarian Cancer Pathogenesis.”

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N.C. Children's Hospital achieves high rankings in several specialties including cancer

Congratulations to the N.C. Children’s Hospital for receiving top rankings in 10 out of 10 clinical categories in U.S. News & World Report’s 2012-13 “America’s Best Children’s Hospitals” list. The N.C. Children’s Hospital is ranked 26th in cancer.

N.C. Children's Hospital achieves high rankings in several specialties including cancer - Read More…

Over 150 attend UNC Lineberger's annual scientific retreat

Over 150 attend UNC Lineberger's annual scientific retreat

More than 150 faculty, students, and fellows gathered in the Alumni Center to hear talks on HPV and Cancer given by UNC Lineberger scientists from basic, translational science, clinical, population science, and global perspectives.

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Science, surgery, and start-ups - in depth with Dr. Nancy DeMore

Science, surgery, and start-ups - in depth with Dr. Nancy DeMore

UNC surgeon-scientist Dr. Nancy DeMore says, “As a physician, I’m acutely aware of how much more we need to learn about breast cancer and how urgently we need better therapies. It really gives me hope to be in the lab and to know that I’m working towards something that may make things better for patients.”

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UNC Oncology Chaplain Named North Carolina Chaplain of the Year

UNC Oncology Chaplain Named North Carolina Chaplain of the Year

Chapel Hill - Patricia Cadle, MRE, BCC, Oncology Chaplain at UNC Health Care’s Department of Pastoral Care, was honored as the 2012 Chaplain of the Year by the North Carolina Chaplains’ Association. This award is presented annually at the Association’s spring conference in recognition of “distinguished ministry in pastoral care” to a chaplain “who serves patients, community and colleagues with grace and innovation.”

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BCBSNC Names Dr. Lisa Carey to Board of Trustees

BCBSNC Names Dr. Lisa Carey to Board of Trustees

CHAPEL HILL, N.C. – Blue Cross and Blue Shield of North Carolina (BCBSNC) has announced Dr. Lisa Carey, Medical Director of the University of North Carolina at Chapel Hill (UNC) Breast Center and Associate Director of UNC Lineberger Comprehensive Cancer Center, as the newest member of its board of trustees.

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Discovery Suggests New Combination Therapy Strategy for Basal-Like Breast Cancers

Discovery Suggests New Combination Therapy Strategy for Basal-Like Breast Cancers

Chapel Hill, NC – Multiple research projects – including a 2006 study conducted at the University of North Carolina at Chapel Hill – have used DNA microarray analysis to identify several breast cancer subtypes, including luminal A, luminal B, basal-like and HER2-enriched. Simple tests are being developed to help doctors identify these subtypes and to treat their patients in a more biologically-based way. In turn, these tests have made several studies possible that indicate that basal-like, or triple negative breast cancer, is more prevalent in African Americans than their Caucasian counterparts.

Discovery Suggests New Combination Therapy Strategy for Basal-Like Breast Cancers - Read More…

Quest to understand Hepatitis C link with liver cancer receives $2.35 million boost

Quest to understand Hepatitis C link with liver cancer receives $2.35 million boost

Chapel Hill, NC – Does hepatitis C cause liver cancer due to inflammation associated with the disease, or does the virus interact with host cells in a different way to promote the development of cancer?

Quest to understand Hepatitis C link with liver cancer receives $2.35 million boost - Read More…

Bae-Jump to serve on NCI's Gynecologic Cancer Steering Committee

Bae-Jump to serve on NCI's Gynecologic Cancer Steering Committee

Victoria Bae-Jump, MD, PhD will serve a two-year term as a junior investigator on the Gynecologic Cancer Steering Committee of the National Cancer Institute, a member institute of the National Institutes of Health.

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UNC study highlights diagnosis of lung cancer subtypes

UNC study highlights diagnosis of lung cancer subtypes

In the processes of treating most cancers, one of the key pieces of information is the appearance of the tumor under the microscope using a technique called light microscopy. In lung cancer, for example, the appearance of the tumor determines both which chemotherapies are safe and which chemotherapies are effective. In addition, tumor appearance also suggests which patients should be tested for mutations that can be targeted by some of the most effective and safest drugs on the market.

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Norman E. Sharpless, MD, appointed the Wellcome Distinguished Professor in Cancer Research

Norman E. Sharpless, MD, appointed the Wellcome Distinguished Professor in Cancer Research

Chapel Hill, NC – Norman E. “Ned” Sharpless, MD, professor of medicine and genetics and Associate Director for Translational Research at UNC Lineberger Comprehensive Cancer Center has been appointed the Wellcome Distinguished Professor in Cancer Research. The professorship was established by the School of Medicine in 1988 with gifts from the Burroughs Wellcome Fund and the William A. Smith Trust of Wadesboro, NC. The gifts were supplemented by the state of North Carolina the Distinguished Professors Endowment Trust Fund to create the endowed professorship.

Norman E. Sharpless, MD, appointed the Wellcome Distinguished Professor in Cancer Research - Read More…

DNA replication protein also has a role in mitosis, cancer

DNA replication protein also has a role in mitosis, cancer

The finding presents a possible explanation for why so many cancers possess not just genomic instability, but also more or less than the usual 46 DNA-containing chromosomes.

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Grant to fund use of kinase test in HER2-positive breast cancer

Grant to fund use of kinase test in HER2-positive breast cancer

Chapel Hill, NC – Susan G. Komen for the Cure® has awarded a grant of almost $900,000 to Lisa A. Carey, MD, and Gary Johnson, PhD, to research clinical applications for the first broad-based test for protein kinase activation and response to inhibitory drugs in HER2-positive breast cancer.

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Study shows benefit of new maintenance therapy for multiple myeloma

Study shows benefit of new maintenance therapy for multiple myeloma

Chapel Hill, NC – Multiple myeloma is a form of cancer where the plasma cells in the bone marrow grow out of control, causing damage to bones as well as predisposing patients to anemia, infection and kidney failure. A medical procedure called autologous hematopoietic stem cell transplantation, commonly known as a stem cell transplant, is frequently an important treatment option for many patients.

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Molecular subtypes and genetic alterations may determine response to lung cancer therapy

Molecular subtypes and genetic alterations may determine response to lung cancer therapy

Chapel Hill - Cancer therapies targeting specific molecular subtypes of the disease allow physicians to tailor treatment to a patient’s individual molecular profile. But scientists are finding that in many types of cancer the molecular subtypes are more varied than previously thought and contain further genetic alterations that can affect a patient’s response to therapy.

Molecular subtypes and genetic alterations may determine response to lung cancer therapy - Read More…

UNC Bone Marrow and Stem Cell Transplantation Program achieves outstanding outcomes

Chapel Hill, NC –A medical procedure called allogeneic hematopoietic cell transplantation, commonly known as a bone marrow or stem cell transplant, is the only known curative option for many patients with life-threatening blood-borne cancers such as leukemia and lymphoma.

UNC Bone Marrow and Stem Cell Transplantation Program achieves outstanding outcomes - Read More…