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Scientists discover diverse stem cell populations within the mouth

December 5, 2019

A multidisciplinary team of investigators, including from the University of North Carolina Lineberger Comprehensive Cancer Center, the Vanderbilt University Medical Center, King’s College and the University of California, San Francisco, has discovered how mouth stem cells may uniquely be equipped to help improve healing in other parts of the body after disease or injury.  The … Continued

Tar Heal Tuesday

December 3, 2019

Tar Heal Tuesday is how UNC celebrates the international day of giving, Giving Tuesday! For the past seven years, nonprofits and charities all over the globe have celebrated Giving Tuesday on the Tuesday after Thanksgiving in order to kick off the season of giving. UNC Lineberger is doing our part today to secure a healthier … Continued

NCBiotech awards grant to Pecot for studies of experimental RNAi therapy

December 2, 2019

The North Carolina Biotechnology Center awarded $100,000 to UNC Lineberger Comprehensive Cancer Center’s Chad Pecot, MD, to study an experimental treatment that would silence a gene commonly mutated in cancer. Using a Nobel Prize-winning technology called RNA interference or RNAi, Pecot’s lab designed an investigational drug to shut down the mutated version of the KRAS … Continued

UNC Lineberger faculty honored for highly cited research

December 1, 2019

The Web of Science Group’s 2019 Highly Cited Researchers list recognized 18 UNC Lineberger members for being among the world’s most influential researchers of the past decade. The listing is limited to researchers who have published multiple highly-cited papers that rank in the top 1 percent by citations for field and year. Approximately only 6,200 … Continued

Der named AAAS Fellow

November 26, 2019

The honor recognizes Der’s contributions to cancer research. His lab’s recent findings on pancreatic cancer have led to clinical studies of a new treatment.

Pancreatic cancer tumor classification could optimize treatment choices

November 21, 2019

In Clinical Cancer Research, a journal of the American Association for Cancer Research, Jen Jen Yeh, MD, and Naim Rashid, PhD, reported findings for how two subtypes of pancreatic cancer respond to treatments differently. Importantly, they found that one subtype of the disease showed poor responses to common therapies and also had worse survival outcomes.

Findings could help identify which aggressive breast cancers will respond to immune treatments

November 14, 2019

University of North Carolina Lineberger Comprehensive Cancer Center researchers have discovered a promising method to identify aggressive breast cancer tumors that will respond to drugs that unleash the immune system against cancer. The U.S. Food and Drug Administration recently approved a treatment that combines an immunotherapy drug and chemotherapy for triple negative breast cancer, but … Continued

Feast or famine: Scientists find key bio ‘switch’ that helps cells adapt

November 5, 2019

Scientists from the UNC School of Medicine and Stanford University have uncovered what may be a fundamental biological mechanism that helps organisms adapt to rapid changes to nutrients in their environments. In a study published in Molecular Cell, the scientists found that a chemical mark on histones – a key protein involved in the function of our … Continued

Researchers use genetic insights to develop model for HPV-linked head and neck cancer

November 5, 2019

A University of North Carolina Lineberger Comprehensive Cancer Center-led research team has used genetic insights about head and neck cancers linked to HPV, or human papillomavirus, to improve laboratory tools for studying the disease. Leveraging their discovery that different subtypes of HPV-linked oropharyngeal squamous cell carcinoma exist based on the expression levels of two different … Continued