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Dan Hollern, PhD, and Charles Perou, PhD

November 14, 2019

Findings could help identify which aggressive breast cancers will respond to immune treatments

University of North Carolina Lineberger Comprehensive Cancer Center researchers have discovered a promising method to identify aggressive breast cancer tumors that will respond to drugs that unleash the immune system against cancer. The U.S. Food and Drug Administration recently approved a treatment that combines an immunotherapy drug and chemotherapy for triple negative breast cancer, but …

Headshot of Antonio Amelio

November 5, 2019

Researchers use genetic insights to develop model for HPV-linked head and neck cancer

A University of North Carolina Lineberger Comprehensive Cancer Center-led research team has used genetic insights about head and neck cancers linked to HPV, or human papillomavirus, to improve laboratory tools for studying the disease. Leveraging their discovery that different subtypes of HPV-linked oropharyngeal squamous cell carcinoma exist based on the expression levels of two different …

Headshot of Matthew Painschab

October 21, 2019

NIH awards grant to Painschab to improve multicentric Castleman disease treatment in Malawi

The National Institutes of Health Fogarty International Center has awarded Matthew Painschab, MD, a five-year International Research Scientist Development Award to lead research into improving treatment for multicentric Castleman disease in Malawi. Working through the University of North Carolina Project-Malawi, a collaboration between UNC-Chapel Hill and the Malawi Ministry of Health, Painschab will lead a …

Jen Jen Yeh

October 21, 2019

Researchers develop method for separating tissue types in tumor samples

A dense web of tissue can surround pancreatic cancer tumors, impeding treatment and sometimes acting as a barrier to the tumor’s spread. Jen Jen Yeh, MD, and colleagues have published a paper in Nature Communications that demonstrates their novel approach to distinguishing cancerous tissue from the surrounding connective tissue and stromal cells as well as from immune cells in the tumor’s environment in order to drive personalized treatment strategies.