Charles M. Perou

Breast Cancer Research, Cancer Genetics, Bioinformatics, Genomics, Epidemiology and Clinical Research

PhD
The May Goldman Shaw Distinguished Professor of Molecular Oncology
Co-Director of the Computational Medicine Program
Department of Genetics
Department of Pathology & Laboratory Medicine
School of Medicine
Breast Cancer
Cancer Genetics

Area of interest

Perou’s research crosses the disciplines of genomics, genetics, cancer biology, bioinformatics, epidemiology, and clinical research. A major contribution of his has been in the characterization of the genomic diversity of breast tumors, which resulted in the discovery of the intrinsic subtypes of breast cancer. He and his colleagues demonstrated that breast cancers can be divided into at least five molecular subtypes using the “PAM50” assay, with his lab focusing particular experimental attention on the Basal-like subtype, which is the majority subtype present within Triple Negative Breast Cancers. He has elucidated many of the genetic causes that give rise to each molecular subtypes, modeled these in Mouse Models, and then used these models to investigate tumor biology, immune system interactions, and the efficacy of novel drug combinations. Perou has translated these molecular finding into the human population using a North Carolina population-based study (i.e. the Carolina Breast Cancer Study), where he and his colleagues have found that African Americans were diagnosed with Basal-like Breast Cancers approximately twice as often as those of European decent. These studies have provided insights into the causes of the racial outcomes disparities differences seen in the USA.

Awards and Honors

  • OncLive Giants of Cancer Care Award, Chicago, IL (2019)
  • Association of American Cancer Institutes Distinguished Scientist Award, Chicago, IL (2018)
  • Brinker Award for Scientific Distinction in Basic Research from the Susan G. Komen (2016)
  • Jill Rose Award for Distinguished Biomedical Research from the BRCF (2016)
  • Thomson Reuters Most Highly Cited Researchers (Top 1% in Clinical Medicine) (2014-18)
  • Hyman L. Battle Distinguished Cancer Research Award from UNC (2013)
  • The European Institute of Oncology Breast Cancer Therapy Award (2012)
  • Danaher Scientific & Medical Award from the Susan G. Komen (2011)
  • AACR Outstanding Investigator Award for Breast Cancer Research (2009)
  • Ruth and Phillip Hettleman Prize for Artistic and Scholarly Achievement from UNC (2006)

Reach NC Profile

Find publications on Pubmed

  • Phone Number

    919-843-5740 (Office Phone)

  • Address

    UNC Lineberger Comprehensive Cancer Center

    Marsico Hall, 5th floor 5111, 125 Mason Farm Road

    CB #7599

    Chapel Hill, NC 27599