Cancer Genetics Clinical Program Archives - Page 4 of 5

Charles M. Perou, PhD, a UNC Lineberger member and a professor of genetics, pathology and laboratory medicine at the UNC School of Medicine, was a co-corresponding author of a study recognized by the Clinical Research Forum.

A cancer genomics study led by UNC Lineberger researchers and other scientists involved in The Cancer Genome Atlas (TCGA) project, a National Cancer Institute and National Human Genome Research Institute-backed effort to create a comprehensive atlas of the genetic changes in cancer, was selected as one of the top 10 clinical research achievements of the year. The project characterized molecular changes in 12 different cancers and revealed a new approach to classifying cancers.

William Kim, MD, a UNC Lineberger member and an associate professor of medicine and genetics at the UNC School of Medicine, spoke on UNC’s findings of molecular subtypes of bladder cancer at UNC Lineberger's 39th annual symposium.

UNC Lineberger's 39th annual scientific symposium was held April 8-9 at the William and Ida Friday Center for Continuing Education in Chapel Hill.

Using human cancer cell lines, UNC scientists identified various ways that HER2-positive breast cancer tumors resist therapy, and they discovered a potential combination therapy to overcome multiple mechanisms of resistance and kill cancer cells.

A UNC Lineberger-led study found that people with higher-risk melanoma containing either BRAF or NRAS gene mutations had lower survival rates.

UNC sequenced the RNA for 10,000 tumor samples as part of The Cancer Genome Atlas project, a National Cancer Institute and National Human Genome Research Institute-backed effort to create a comprehensive atlas of the genetic changes in cancer.

Brian Strahl, PhD, and his band of biochemists unravel the complicated mysteries of the epigenetic code to find a culprit in cancer development.

Sixteen years after scientists found the genes that control the circadian clock in all cells, the lab of UNC’s Aziz Sancar, MD, PhD, discovered the mechanisms responsible for keeping the clock in sync.

Researchers with The Cancer Genome Atlas (TCGA) Research Network have completed the largest, most diverse tumor genetic analysis ever conducted, revealing a new approach to classifying cancers. The work, led by researchers at the UNC Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill and other TCGA sites, not only revamps traditional ideas of how cancers are diagnosed and treated, but could also have a profound impact on the future landscape of drug development.

The ability of researchers and physicians to use DNA sequencing to pinpoint the genetic mutations that cause cancer has led to greater understanding of the causes of the disease and development of drugs that treat tumors by targeting specific mutations. A pair of papers published by researchers at the UNC Lineberger Comprehensive Cancer Center reveal new tools that can improve the accuracy of tumor sequencing.

Previously thought to only play a role in male fertility, the protein DAZAP1 has now been shown to be a major player in how genes are expressed; in cell culture experiments it stifled the progression of several types of cancer cells.

Tag: Cancer Genetics Clinical Program

Clinical Research Forum selects genomic analysis as top 10 research achievement

Cancer genetics the focus of UNC Lineberger symposium

Researchers find new approach to treat drug-resistant HER2-positive breast cancer

Lower survival rates connected with high-risk melanoma with mutations, study finds

UNC Lineberger sequences 10,000 tumors as part of national cancer genomics effort

All the Cell’s a Stage

UNC researchers find final pieces to the circadian clock puzzle

Largest cancer genetic analysis reveals new way of classifying cancer

UNC-developed tools improve accuracy of cancer DNA sequencing

UNC researchers discover “master regulator” role for little-known protein in cancer cells