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Chad Pecot, MD

November 13, 2014

UNC researchers create new technique to silence leading cancer-causing gene

UNC Lineberger researchers and colleagues at The University of Texas MD Anderson Cancer Center have developed a new approach to block the KRAS oncogene, one of the most frequently mutated genes in human cancer. The approach, led by Chad Pecot, MD, an assistant professor of medicine at UNC, offers another route to attack KRAS, which has proven to be an elusive and frustrating target for drug developers.

August 24, 2014

UNC Lineberger researchers develop new approach to identify “drivers” of cancer

UNC Lineberger Comprehensive Cancer Center researchers have developed a new integrated approach to pinpoint the genetic “drivers” of cancer, uncovering eight genes that could be viable for targeted breast cancer therapy. The study, published online August 24 in Nature Genetics, was authored by Michael Gatza, PhD, lead author and post-doctoral research associate; Grace Silva, graduate student; Joel Parker, PhD, director of bioinformatics, UNC Lineberger; Cheng Fan, research associate; and senior author Chuck Perou, PhD, professor of genetics and pathology.

May 23, 2014

UNC Lineberger to offer sequencing expertise to NCI clinical trials networks

Personalized medicine holds great promise for delivering targeted treatments to patients based on their unique genetic characteristics. Through a $3.5 million, five-year grant from the National Cancer Institute (NCI), UNC Lineberger Comprehensive Cancer Center will provide high-throughput RNA and DNA sequencing and regulatory assistance to partner institutions in the NCI’s new National Clinical Trials Network (NCTN).