September 16, 2020
Qi Zhang, PhD, Robert McGinty, MD, PhD, and team determined the high-resolution structure of a key DNA-sensing protein in the innate immune system called cGAS while it is bound to the nucleosome.
February 3, 2020
Cancer genetic testing revealed that Beth Silverstein was at high risk for breast and ovarian cancer. She took charge of her destiny and took preventive steps through surgery, and now celebrates five years as a "previvor" with a fundraiser for UNC Lineberger.
January 24, 2019
In preliminary findings presented at the 2018 San Antonio Breast Cancer Symposium, researchers led by UNC Lineberger's Charles M. Perou, PhD, and Susana Garcia-Recio, PhD, reported they found increased expression of the gene FGFR4 in metastatic breast cancer tumors.
November 19, 2018
Using technology similar to the type that powers facial recognition on a smartphone, Charles M. Perou, PhD, Melissa Troester, PhD, and Heather D. Couture have trained a computer to analyze breast cancer images and then classify the tumors with high accuracy.
April 9, 2018
UNC Lineberger's Shawn Ahmed, PhD, was senior author of a study that published in Cell Reports on April 3. Ahmed, former UNC Lineberger postdoctoral fellow Bree Heestand and colleagues demonstrate in the study "Transgenerational sterility of Piwi mutants represents a dynamic form of Adult Reproductive Diapause" that reproductive arrest in adults can also occur in response to a form of "heritable stress" that is transmitted by germ cells, which likely represents a form of epigenomic damage.
April 5, 2018
A study by researchers from The Cancer Genome Atlas (TCGA) Network, and led by UNC Lineberger's Katherine Hoadley, PhD, supports an additional classification for human tumors.
April 5, 2018
UNC Lineberger researchers led two major projects to mark the finale of The Cancer Genome Atlas project, which was backed by the National Cancer Institute and National Human Genome Research Institute.
March 7, 2018
UNC Lineberger researchers, including Charles M. Perou, PhD, and Lisa A. Carey, MD, were part of a preclinical study that found blocking the production of asparagine with a drug called L-asparaginase in mice with aggressive triple negative breast tumors, and putting them on a low-asparagine diet, reduced the breast tumor’s ability to spread.
March 5, 2018
In the Journal of Clinical Investigation, UNC Lineberger researchers Lisa A. Carey, MD, Charles M. Perou, PhD, and Carey Anders, MD, Marni Siegel and colleagues published their analysis of the genetic differences they discovered in patients’ primary breast cancers and their metastatic cancers.
September 1, 2016
Researchers led by UNC Lineberger Director Norman Sharpless, MD, and William Wood, MD, uncovered clues that suggest that stem cell transplant is linked to a marked increase in the “molecular age” of these immune cells in a group of patients with blood cancer.
