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Researchers identify driver of a key change in metastatic breast cancer

January 24, 2019

In preliminary findings presented at the 2018 San Antonio Breast Cancer Symposium, researchers led by UNC Lineberger’s Charles M. Perou, PhD, and Susana Garcia-Recio, PhD, reported they found increased expression of the gene FGFR4 in metastatic breast cancer tumors.

Scientists train a computer to classify breast cancer tumors

November 19, 2018

Using technology similar to the type that powers facial recognition on a smartphone, Charles M. Perou, PhD, Melissa Troester, PhD, and Heather D. Couture have trained a computer to analyze breast cancer images and then classify the tumors with high accuracy.

Ahmed published in Cell Reports

April 9, 2018

UNC Lineberger’s Shawn Ahmed, PhD, was senior author of a study that published in Cell Reports on April 3. Ahmed, former UNC Lineberger postdoctoral fellow Bree Heestand and colleagues demonstrate in the study “Transgenerational sterility of Piwi mutants represents a dynamic form of Adult Reproductive Diapause” that reproductive arrest in adults can also occur in response to a form of “heritable stress” that is transmitted by germ cells, which likely represents a form of epigenomic damage.

To halt breast cancer’s spread, scientists block amino acid found in asparagus

March 7, 2018

UNC Lineberger researchers, including Charles M. Perou, PhD, and Lisa A. Carey, MD, were part of a preclinical study that found blocking the production of asparagine with a drug called L-asparaginase in mice with aggressive triple negative breast tumors, and putting them on a low-asparagine diet, reduced the breast tumor’s ability to spread.

Blood cancer treatment may age immune cells as much as 30 years

September 1, 2016

Researchers led by UNC Lineberger Director Norman Sharpless, MD, and William Wood, MD, uncovered clues that suggest that stem cell transplant is linked to a marked increase in the “molecular age” of these immune cells in a group of patients with blood cancer.