UNC Lineberger’s Shawn Ahmed, PhD, was senior author of a study that published in Cell Reports on April 3. Ahmed, former UNC Lineberger postdoctoral fellow Bree Heestand and colleagues demonstrate in the study “Transgenerational sterility of Piwi mutants represents a dynamic form of Adult Reproductive Diapause” that reproductive arrest in adults can also occur in response to a form of “heritable stress” that is transmitted by germ cells, which likely represents a form of epigenomic damage.
UNC Lineberger researchers, including Charles M. Perou, PhD, and Lisa A. Carey, MD, were part of a preclinical study that found blocking the production of asparagine with a drug called L-asparaginase in mice with aggressive triple negative breast tumors, and putting them on a low-asparagine diet, reduced the breast tumor’s ability to spread.
In the Journal of Clinical Investigation, UNC Lineberger researchers Lisa A. Carey, MD, Charles M. Perou, PhD, and Carey Anders, MD, Marni Siegel and colleagues published their analysis of the genetic differences they discovered in patients’ primary breast cancers and their metastatic cancers.
Each month, the technology company IBM releases a podcast called “Wild Ducks,” focusing on world-changing people and ideas. For the month of July, IBM came to UNC Lineberger Comprehensive Cancer Center to learn about personalized medicine and meet their newest Wild Duck – Ned Sharpless, MD, UNC Lineberger Director and Wellcome Distinguished Professor in Cancer Research at the UNC School of Medicine.