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Channing Der heashot

November 18, 2019

Researchers find KRAS gene mutation differences have implications for pancreatic cancer treatment

The KRAS gene is commonly mutated in cancer. In the journal Cancer Discovery, researchers led by Channing Der, PhD, and Aaron Hobbs, PhD, reported details of the role of the KRAS G12R mutation in pancreatic cancer, and therapeutic strategies that might work for this mutation type. By studying unique differences in DNA mutations within the same gene, researchers are working to uncover the mutation-specific mechanisms that drive cancerous growth.

Jen Jen Yeh

October 21, 2019

Researchers develop method for separating tissue types in tumor samples

A dense web of tissue can surround pancreatic cancer tumors, impeding treatment and sometimes acting as a barrier to the tumor’s spread. Jen Jen Yeh, MD, and colleagues have published a paper in Nature Communications that demonstrates their novel approach to distinguishing cancerous tissue from the surrounding connective tissue and stromal cells as well as from immune cells in the tumor’s environment in order to drive personalized treatment strategies.