Researchers lay the foundation for personalized immune treatments for leukemia

August 29, 2018

In the journal Blood Advances, UNC Lineberger’s Ben Vincent, MD, Paul Armistead, MD, PhD, and their collaborators reported early findings from a new study that could aid in the development of immune-based treatments that are tailored to individual leukemia patients who are undergoing stem cell transplantation.

Stem cells show promise as drug delivery tool for childhood brain cancer

August 27, 2018

UNC Lineberger’s Shawn Hingtgen, PhD, and his collaborators showed they could shrink tumors in laboratory models of medulloblastoma, and extend life. The study, published in PLOS ONE, is a necessary step toward developing clinical trials that would see if the approach works for children.

Researchers clarify role of mutations in glioblastoma

July 10, 2018

In a preclinical study, researchers led by UNC Lineberger’s Ryan Miller, MD, PhD, investigated whether the location of where the mutation occurred within the sequence of the PIK3CA gene affected the mutation’s ability to help drive cancerous growth. They also evaluated whether the location of the mutation would affect the cancer’s response to certain treatments.

Researchers map the genome of testicular cancer

June 12, 2018

In a collaborative, multi-institution effort to map the genetic and genomic changes in cancer, researchers led by UNC Lineberger’s Katherine Hoadley, PhD, analyzed 137 testicular germ cell tumors for potential mutations and other molecular changes. They identified molecular features of testicular germ cell cancers that could inform future efforts to improve treatment decisions, and help monitor patients to see if their cancer has come back. Their findings were published in Cell Reports.

Blood mutations could contaminate genetic analyses of tumors

June 4, 2018

UNC Lineberger researchers and colleagues led by Catherine C. Coombs, MD, reported research findings at the 2018 American Society of Clinical Oncology Annual Meeting that showed blood cell mutations accounted for as many as 8 percent of the mutations identified in large-scale genetic sequencing efforts at two major academic centers.

By forming clots in tumors, immune cells aid lung cancer’s spread

May 24, 2018

Researchers led by UNC Lineberger’s Chad Pecot, MD, report in the journal Nature Communications that for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These cells, which normally help to build clotting scaffolds to promote wound healing, also make it possible for tumor cells to migrate and spread to other parts of the body.

Bladder cancer model could pave the way for better drug efficacy studies

May 21, 2018

In the journal Cancer Research, UNC Lineberger’s William Y. Kim, MD, Benjamin G. Vincent, MD, and colleagues reported they have developed a mouse model of luminal bladder cancer, one of the two subtypes of advanced bladder cancer. The researchers said this model may help them to determine which patients may respond to immunotherapy treatments called checkpoint inhibitors.