February 3, 2020
Tumors can create a hostile environment for cancer-fighting immune cells. In a new study, University of North Carolina Lineberger Comprehensive Cancer Center researchers have developed a method for engineering immune cells to improve their survival and proliferation, even within a hostile tumor. Researchers led by UNC Lineberger’s Gianpietro Dotti, MD, report in the journal Nature …
November 5, 2019
A University of North Carolina Lineberger Comprehensive Cancer Center-led research team has used genetic insights about head and neck cancers linked to HPV, or human papillomavirus, to improve laboratory tools for studying the disease. Leveraging their discovery that different subtypes of HPV-linked oropharyngeal squamous cell carcinoma exist based on the expression levels of two different …
October 1, 2019
UNC Lineberger researchers published new findings in Nature Communications that help explain one path that breast cancers can take as they leave tumors and spread throughout the body.
September 12, 2019
Scientists at the University of North Carolina Lineberger Comprehensive Cancer Center have designed and validated a model for predicting what might make an effective cancer vaccine against a patient’s tumor. This finding could help overcome a significant obstacle in the development of personalized cancer vaccines. In a study published in the journal Cancer Immunology Research, …
July 22, 2019
Researchers at the UNC Lineberger Comprehensive Cancer Center have discovered a hyperactive cell signal that contributes to tumor growth in an aggressive blood cancer. They also developed an experimental therapeutic to block the signal and slow tumor growth. In the journal Proceedings of the National Academy of Sciences, the researchers reported they have identified a …
July 12, 2019
A new study led by UNC Lineberger’s Antonio “Tony” Amelio, PhD, and colleagues was published in the journal Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, and featured on the cover of the July issue. Amelio is an assistant professor in the UNC Adams School of Dentistry Division of Oral and Craniofacial Health Sciences. …
July 12, 2019
University of North Carolina Lineberger Comprehensive Cancer Center researchers have published a review of experimental cancer vaccines that identified areas of promise and challenges for the field. In the Nature Reviews Cancer, researchers outlined current research into targets for therapeutic cancer vaccines, an area of active investigation focused on boosting immune responses to cancer. “Generally, …
June 13, 2019
Using a new blood test that’s in development, University of North Carolina Lineberger Comprehensive Cancer Center researchers identified characteristics that could be used to personalize treatment for patients with a type of head and neck cancer linked to HPV infection. Researchers believe the findings, published in the journal Clinical Cancer Research, could help identify those …
April 19, 2019
The idea was simple: find the faulty signals that drive cancerous growth in cells, and block them. But what University of North Carolina Lineberger Comprehensive Cancer Center researcher Pengda Liu, PhD, has discovered, when it comes to cancer, even straightforward concepts can become complicated. “When you find a target and inhibit it, you find the …
April 17, 2019
A study by University of North Carolina Lineberger Comprehensive Cancer Center researchers helps explain how tumors recruit blood vessels that provide fuel for their growth as well as an avenue for the tumors to spread. In the journal Oncogene, the researchers also reported they built on these findings to uncover a potential treatment strategy to …
