Researchers use genetic insights to develop model for HPV-linked head and neck cancer

November 5, 2019

A University of North Carolina Lineberger Comprehensive Cancer Center-led research team has used genetic insights about head and neck cancers linked to HPV, or human papillomavirus, to improve laboratory tools for studying the disease. Leveraging their discovery that different subtypes of HPV-linked oropharyngeal squamous cell carcinoma exist based on the expression levels of two different … Continued

Can scientists predict which cancer markers are likely to trigger an immune response?

September 12, 2019

Scientists at the University of North Carolina Lineberger Comprehensive Cancer Center have designed and validated a model for predicting what might make an effective cancer vaccine against a patient’s tumor. This finding could help overcome a significant obstacle in the development of personalized cancer vaccines. In a study published in the journal Cancer Immunology Research, … Continued

Researchers unveil experimental compound to block therapeutic target in blood cancer

July 22, 2019

Researchers at the UNC Lineberger Comprehensive Cancer Center have discovered a hyperactive cell signal that contributes to tumor growth in an aggressive blood cancer. They also developed an experimental therapeutic to block the signal and slow tumor growth. In the journal Proceedings of the National Academy of Sciences, the researchers reported they have identified a … Continued

Amelio published in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

July 12, 2019

A new study led by UNC Lineberger’s Antonio “Tony” Amelio, PhD, and colleagues was published in the journal Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, and featured on the cover of the July issue. Amelio is an assistant professor in the UNC Adams School of Dentistry Division of Oral and Craniofacial Health Sciences. … Continued

Scientists publish overview of the latest in cancer vaccine target research

July 12, 2019

University of North Carolina Lineberger Comprehensive Cancer Center researchers have published a review of experimental cancer vaccines that identified areas of promise and challenges for the field. In the Nature Reviews Cancer, researchers outlined current research into targets for therapeutic cancer vaccines, an area of active investigation focused on boosting immune responses to cancer. “Generally, … Continued

Researchers identify traits linked to better outcomes in HPV-linked head and neck cancer

June 13, 2019

Using a new blood test that’s in development, University of North Carolina Lineberger Comprehensive Cancer Center researchers identified characteristics that could be used to personalize treatment for patients with a type of head and neck cancer linked to HPV infection. Researchers believe the findings, published in the journal Clinical Cancer Research, could help identify those … Continued

Study provides insights behind hyperactivation of key cell proliferation signal

April 19, 2019

The idea was simple: find the faulty signals that drive cancerous growth in cells, and block them. But what University of North Carolina Lineberger Comprehensive Cancer Center researcher Pengda Liu, PhD, has discovered, when it comes to cancer, even straightforward concepts can become complicated. “When you find a target and inhibit it, you find the … Continued

New details revealed to explain how tumors recruit blood vessels

April 17, 2019

A study by University of North Carolina Lineberger Comprehensive Cancer Center researchers helps explain how tumors recruit blood vessels that provide fuel for their growth as well as an avenue for the tumors to spread. In the journal Oncogene, the researchers also reported they built on these findings to uncover a potential treatment strategy to … Continued

Scientists discover key enzyme in breast cancer proliferation, treatment resistance

March 12, 2019

Basal-like breast cancer is the most aggressive and difficult-to-treat subtype of breast cancer, and it largely overlaps with the triple-negative classification of the disease. Patients are in dire need of improved therapies that attack the underlying cellular features of these types of breast cancer. Now scientists at the University of North Carolina Lineberger Comprehensive Cancer … Continued

New studies aim to improve melanoma diagnosis

February 28, 2019

A pair of studies led by University of North Carolina Lineberger Comprehensive Cancer Center researchers could aid in improved diagnosis for melanoma, the deadliest form of skin cancer. The studies, led by UNC Lineberger’s Nancy Thomas, MD, PhD, Irene & Robert Alan Briggaman Distinguished Professor and Chair in the UNC School of Medicine Department of … Continued