UCRF News - UNC Lineberger

UNC researchers discover an enzyme that protects DNA during rapid cell divisions

Michael Emanuele, PhD, and colleagues have discovered that an enzyme called USP37 plays a crucial role in ensuring our cells copy their DNA correctly.

Ewing's sarcoma that has metastasized to the pleura fluid.

Researchers develop molecule that targets Ewing sarcoma

Pengda Liu, PhD, and colleagues have created a small molecule that targets and breaks down a protein linked to Ewing sarcoma, an aggressive cancer that mostly affects children and teens.

Human cells with acute myelocytic leukemia (AML) in the pericardial fluid, shown with an esterase stain at 400x magnification.

Adaptive whole-genome sequencing could transform childhood leukemia diagnosis

UNC Lineberger researchers have demonstrated a faster, more cost-effective approach to analyzing the genetic makeup of pediatric acute leukemia. Determining a cancer’s genomic classification is critical to developing a more effective treatment plan tailored to a patient’s tumor.

Scientific illustration of a CAR-T cell attacking a cancer cell.

Three drug cocktail shows potential to boost CAR-T cancer therapy

Gianpietro Dotti, MD, and colleagues report in Nature Immunology they have identified a cocktail of three different drugs that can be used to generate more robust CAR-Ts to fight cancer.

A clinical staff talks with a soldier in a clinic exam room.

Improving health of military personnel and families through collaboration, research

UNC Lineberger is leading an innovative cancer prevention partnership at Fort Bragg that is designed to reduce tobacco use and promote HPV vaccination.

A woman holds a stamped, padded mailer envelope.

Home testing kits and coordinated outreach substantially improve colorectal cancer screening rates

Previous research has shown this kind of intervention is effective in large, integrated health systems. However, its impact was unknown in federally qualified health centers and the patient populations they serve.

Kim, Rose highlight advances in kidney cancer research and care in JAMA

William Kim, MD, and Tracy Rose, MD, MPH, published a review highlighting new scientific insights that have led to advances in kidney cancer treatment and increased survival rates.

Exteriors of the UNC Lineberger and Marsico Hall buildings.

UNC Lineberger provides $1.3 million in developmental research grants

More than $1.3 million in UNC Lineberger developmental research grants were awarded to 13 faculty members and one postdoctoral trainee this spring.