Stephen Rogers

PhD, Biology, UNC-Chapel Hill, Cancer Cell Biology

Stephen Rogers

UNC-Chapel Hill
Cancer Cell Biology

422 Fordham Hall

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Area of interest

Cancer metastasis is fundamentally a disease of cellular migration. During metastasis, a neoplasm becomes invasive and leaves its point of origin to disseminate throughout the body. Metastatic cancers often have a poor prognosis and victims of the disease typically succumb to tissue injuries caused by secondary tumor growth in different organs or to complications associated with chemotherapeutic treatments. As they spread throughout tissues, cancer cells utilize similar principles of migration as non-transformed cells; thus, if we understand how motility occurs in experimentally tractable model systems, we can begin to devise novel therapeutic strategies to block cancer cell invasiveness and identify specific genes that may contribute to the spread of metastatic cells. The long-term goal of of our research program is to understand the process of cell migration by focusing on how cells regulate cytoskeletal dynamics to build supramolecular structures involved in motility. Current projects revolve around the following three biological processes:

1. Regulation of microtubule dynamics
2. Signaling to the cellular contractile machinery
3. Functional genomic analysis of cellular migration

Awards and Honors

Beckman Young Investigator Award 2008
Basil O' Connor Starter Scholar Award 2006
American Heart Association, Scientist Development Award 2006

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