Cancer Cell Biology
Area of interest
I have a broad background in cell biology, with specific training and expertise in live cell imaging and biochemistry of the microtubule cytoskeleton. Since starting at UNC, my lab has used Drosophila as a model system to study the cell biology of microtubule function and dynamics. We have developed novel cell-based approaches and high-throughput methods to analyze microtubules and their regulatory factors and have made significant contributions to the understanding of microtubule plus end tracking proteins, microtubule depolymerases, polymerases, actin-microtubule cross-linking factors, and severing proteins. We discovered a licensing mechanism for centrosome duplication and characterized defects in cell migration when centrosomes are over duplicated. In addition, we have utilized Drosophila more broadly to study signaling through heterotrimeric G proteins in vivo and identified a G-protein coupled receptor that triggers gastrulation movements in the blastoderm embryo. Thus, our body of work demonstrates expertise in the study of the cytoskeleton and cell signaling from cells to the whole organism using a broad range of approaches.
Awards and Honors
- Beckman Young Investigator Award 2008
- Basil O’ Connor Starter Scholar Award 2006
- American Heart Association, Scientist Development Award 2006