Biochemistry & Biophysics and Pharmacology
Breast Cancer; Cancer Cell Biology; Molecular Therapeutics
Area of interest
Our cancer-related research is focused on a protein called CIB1. Certain cancers appear to be addicted to CIB1 for survival. We have focused most of our work on the role of CIB1 in triple negative breast cancer because of the lack of targeted therapy and need for new approaches with this aggressive cancer. We are currently developing inhibitors of CIB1 for preclinical studies.
We also study small cells in the blood called platelets. Platelets are required for hemostasis, but also contribute to thrombosis in cancer and other disorders. In addition, platelets contribute to tumor growth and metastases. We have discovered a new enzyme in platelets (AADACL1) that regulates platelet aggregation by metabolizing lipids. This enzyme appears to be a drug excellent target for regulating platelet-mediated thrombosis.
Awards and Honors
- 2017-2019 Chair of the Faulty, UNC-CH
- 2018 President elect, AMGDB
- 2013-2016 Associate Editor, Blood
- Associate Editor, Blood Journal
- Advisory Committee, ASBMB
- Fellow, American Association for the Advancement of Science
- Fellow, Executive Leadership in Academic Medicine
- Chair, Biochemistry & Biophysics at UNC-CH