Michael S. Lee

Michael Lee, MD, Assistant Professor, School of Medicine, UNC-Chapel Hill, Molecular Therapeutics

Assistant Professor
UNC-Chapel Hill
Molecular Therapeutics

Area of interest

I am a translational investigator in gastrointestinal cancers, particularly colorectal cancers, focusing on drug development and design of early phase clinical trials of novel therapies. I am a clinical researcher, designing and writing clinical trials in patients with gastrointestinal cancers and designing correlative studies to determine biomarkers of susceptibility or resistance. In addition, I am also involved in the preclinical research necessary for drug development and novel pathophysiologic discoveries. I received a Howard Hughes Research Training Fellowship during medical school studying the effect of transforming growth factor beta on cancer cell invasiveness, and during my oncology fellowship I performed preclinical studies investigating the synergistic combination of the novel targeted drug combination of CDK4/6 inhibitor and MEK inhibitor in KRAS-mutant colorectal cancers. I was awarded a Young Investigator Award from the Conquer Cancer Foundation to continue this research. I will continue to investigate novel combinations of targeted drug therapies, with a focus toward drugs that may be effective in KRAS mutated colorectal cancers. I also have analyzed circulating cytokine and growth factor levels in patients with metastatic colorectal cancer and examined proteomic classifications of colorectal cancers, and I aim to build our blood and tissue banks of gastrointestinal cancers so that we can learn more about the biology and treatments of these diseases.

Awards and Honor

  • 2015 Conquer Cancer Foundation Young Investigator Award
  • 2014 Patricia Hodson Educational Endowment. Travel award for presentation of research in GI oncology, to the 2015 GI Cancers Symposium.
  • 2014 Delegate, AACR/ASCO Vail Workshop: Methods in Clinical Cancer Research
  • 2013 Delegate, AACR Aspen Workshop: Molecular Biology in Clinical Oncology
  • 2009 G.S. Terence Cavanagh Prize, Duke University School of Medicine. Awarded to the graduating student(s) with the highest cumulative grade point average.
  • 2008 Alpha Omega Alpha, Duke University School of Medicine. Inducted as a junior.
  • 2008 Duke University Medical School Senior Scholarship recipient
  • 2007 Howard Hughes Research Training Fellowship for Medical Students
  • 2005 Richard J. Johns Award, Johns Hopkins University. Awarded to the senior students in biomedical engineering with the highest cumulative grade point average.
  • 2004 Alpha Eta Mu Beta, Biomedical Engineering Honor Society
  • 2004 Tau Beta Pi, Engineering Honor Society
  • 2003 Provost’s Undergraduate Research Award, Johns Hopkins University

Link to Publications on PubMed